Terence R J Lappin Selected Research

Erythropoietin

1/2018	A novel splicing site IRP1 somatic mutation in a patient with pheochromocytoma and JAK2V617F positive polycythemia vera: a case report.
6/2013	Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation.
12/2011	Autocrine/paracrine erythropoietin signalling promotes JAK/STAT-dependent proliferation of human cervical cancer cells.
4/2009	Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline.
6/2008	Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis.
2/2007	Impaired downregulation following erythropoietin receptor activation in non-small cell lung carcinoma.
1/2006	A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis.
9/2003	A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation.

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Terence R J Lappin Research Topics

Disease

10	Hypoxia (Hypoxemia) 01/2018 - 09/2003
8	Polycythemia (Erythrocytosis) 06/2013 - 09/2003
3	Neoplasms (Cancer) 01/2018 - 02/2007
2	Leukemia 07/2013 - 10/2005
2	Hyperglycemia 03/2012 - 01/2006
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2007 - 02/2007
2	Anemia 02/2007 - 01/2006
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 07/2013
1	Birth Weight (Birth Weights) 03/2012
1	Pre-Eclampsia (Preeclampsia) 03/2012
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 12/2011
1	Acidosis 07/2010
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2009
1	primary familial and congenital Polycythemia 01/2006
1	Acute Promyelocytic Leukemia 02/2003

Drug/Important Bio-Agent (IBA)

8	Erythropoietin FDA Link 01/2018 - 09/2003
6	Oxygen (Dioxygen)IBA 06/2013 - 09/2003
5	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2018 - 01/2006
3	Protein Isoforms (Isoforms)IBA 06/2013 - 01/2008
3	Transcription Factors (Transcription Factor)IBA 07/2010 - 01/2006
2	Glucose (Dextrose)FDA LinkGeneric 03/2012 - 01/2006
2	C-PeptideIBA 03/2012 - 01/2006
2	EnzymesIBA 07/2010 - 01/2006
2	Proteins (Proteins, Gene)FDA Link 01/2008 - 10/2005
2	Erythropoietin Receptors (Erythropoietin Receptor)IBA 03/2007 - 02/2007
1	Iron Regulatory Protein 1IBA 01/2018
1	entinostat (MS 275)IBA 07/2013
1	ORALIT (ORS)IBA 03/2012
1	Phosphocreatine (Neoton)IBA 07/2010
1	Lactic Acid (Lactate)FDA LinkGeneric 07/2010
1	Proline (L-Proline)FDA Link 04/2009
1	GlucocorticoidsIBA 01/2009
1	endothelial PAS domain-containing protein 1IBA 06/2008
1	AntibodiesIBA 03/2007
1	HematinicsIBA 02/2007
1	Retinoic Acid Receptor alphaIBA 02/2003
1	promyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinIBA 02/2003

Therapy/Procedure

1	Therapeutics 07/2013
1	Cesarean Section (Caesarean Section) 03/2012